FUNCTIONALIZED NICKEL OXIDE NANOMATERIALS FOR BIOMEDICAL APPLICATIONS

Abstract

Functionalized nickel oxide nanoparticles (NiO NPs) hold great promise for biomedical applications due to their unique properties and potential for enhanced biocompatibility. However, further investigation is needed to optimize their functionality in biological systems. In this study, NiO NPs were synthesized and functionalized via the sol-gel method, which is renowned for producing uniform, high-purity nanoparticles. During synthesis, NiCl and NaOH were employed as precursors to generate NiO NPs. Comprehensive characterization of the nanoparticles was performed using UV-visible spectroscopy, Fourier transform infrared spectroscopy (FT-IR), and X-ray diffraction (XRD) techniques to assess their structural, compositional, and functionalization properties. The results revealed that functionalized NiO NPs exhibited improved biocompatibility, stability, and efficacy, making them suitable candidates for biomedical applications. Structural analysis confirmed the preservation of nanoparticle integrity after functionalization, while statistical evaluation indicated significant enhancements in key parameters compared to non-functionalized counterparts. These findings demonstrate the potential of sol-gel-synthesized functionalized NiO NPs to advance nanoparticle-based medical therapies and suggest a promising avenue for their development in early-stage biomedical treatments.